p 06 Bacterial retention strategy Challenging the filter Bacterial retention studies give us accurate analysis of how a diminutive organism will respond in a given fluid. The fluid characteristics have a direct impact on cell size and therefore, the filter’s retention capability. Typical change factors may include: • Osmolarity • pH levels • Growth factors • Antimicrobial effects • Temperature • Ionic strength The filter retention may also be influenced by it’s interaction with the process and therefore, the filters tested in the process compatibility stage are used for the bacterial challenge. When carrying out a bacterial challenge test to rate our 0.2 micron sterilizing grade filters, Parker follow guidelines laid out in the current revision of ASTM F838. Providing sterility assurance Tailored bacterial challenge testing, recognizing that each process in unique. parker.com/bioscience
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